Newcastle were in no mood to roll over though and nine minutes after the break they drew level when Liverpool failed to clear a corner and Rondon's brilliant fierce left foot drive beat the helpless Alisson Becker to make it 2-2.
After being in and out of the team all season, Keita had started the last four Premier League games in a row for the Reds, as well as both first legs against Porto and now Barcelona in the Champions League.
Naby Keita is to be assessed after suffering a groin injury during Liverpool's Champions League semi-final defeat to Barcelona at Camp Nou.
Liverpool manager Jurgen Klopp and captain Jordan Henderson are looking to mastermind one of the all-time great Champions League comebacks against Barcelona (Owen Humphreys/PA). It's going to be odd for them coming here with a 3-0 advantage but they still have in their mind that it won't be over.
"It has been [a special season], I'm enjoying every bit of it", added the Dutch centre-half.
Despite playing at home, Barcelona finished with less ball possession than Liverpool, 48 per cent to 52 per cent.
Barcelona president Josep Maria Bartomeu has said the Champions League must undergo changes to ensure elite teams face each other more often and remains committed to the idea of playing La Liga matches overseas.
Speaking after the game, Klopp was unsure whether Keita would be involved again this campaign, insisting: "We have to see".
Virgil van Dijk expects a "different challenge" at St James' Park to the one they came up against at the Camp Nou.
Liverpool boss Klopp surprised everyone by utilising midfielder Wijnaldum in a central attacking role, with first-choice forward Roberto Firmino named only amongst the substitutes.
The Dutchman was fantastic at Southampton, but we could see all the way back in his Celtic days what a good player he was.
"It's similar to previous year, we also have a three-goal advantage, but look what happened then", Valverde said.