Showers will continue through Saturday night, with 1 to 2 inches of rain expected in Western Massachusetts, with some areas having the potential of 2 1/2 inches, the National Weather Service tweeted.
York County could see gusty winds, possible rain and thunderstorms, and localized flash flooding.
Many parts of SC remain under tornado watches and warnings as the storm system moves through the state.
Franklin County officials say they have seven reports of buildings being damaged; two of which are completely destroyed.
Chicago could also see some showers or thunderstorms and winds with gusts up to 25 miles per hour Wednesday evening, the weather service said.
Four people were killed in the storms that touched down in many areas still reeling from last weekend's severe weather and tornadoes. A woman also died in Alabama when a tree fell on her mobile home Thursday. Kenderick Magee, 24, was killed when his vehicle crashed during severe weather in Amite County on Thursday, CNN affiliate WLBT reported.
Damage from the storm system was reported in at least 24 of Mississippi's 82 counties.
The storms are expected in Macon by 5 a.m. and will linger for most of the morning.
The National Weather Service issued a series of tornado warnings about a front pushing eastward from Texas on Thursday.
The same storm system was blamed for the deaths a day earlier of two MS drivers and a woman in Alabama.
Forecasters say the area at highest risk of severe storms and tornadoes Friday is home to 9.7 million people in the Carolinas and Virginia and includes the Charlotte, North Carolina metro area. Most of the storm damage came from strong winds, as gusts neared 70 miles per hour.
Three days of severe storms in the South and Southeast are about to give way to a nice holiday weekend for much of the country. The highest threat exists from the Carolinas into New England, it said.
National Weather Service forecasters said they believe multiple tornadoes hit the southern half of MS on Thursday as a storm system moves east.