"The storm is so vigorous that tornadoes are still possible after dark", Myers said. The Angelina County Sheriff's Office says an 8-year-old and 3-year-old died after the tree hit the back of the vehicle in Lufkin, about 115 miles (185 kilometers) northeast of Houston. The children, ages 8 and 3, were dead at the scene, while both parents, who were in the front seat, escaped injury, he said.
Additional details were not immediately available.
Winds expected to clock in at 40 miles per hour are headed toward New Orleans and surrounding areas as intense thunderstorms make their way east, forecasters said.
At least three children have been killed during an outbreak of severe weather that has been hitting the south this weekend.
Two children, ages 3 and 8, were killed in eastern Texas when a tree fell on the auto in which they were traveling.
ABC News reported two more deaths after a tornado ripped through Hamilton, Mississippi.
Residents have reported downed power lines, cars overturned and homes completely destroyed, KBTX reports.
The storms are part of a large system moving through the southern U.S.
As a strong upper level and surface low pressure system continues to rotate eastward through Texas on Saturday, clusters of thunderstorms developed Saturday morning across much of the state.
The National Weather Service Storm Prediction Center is cautioning that, "Strong tornadoes are possible today into tonight from east Texas into MS, with the greatest threat expected between 2PM-8PM CDT".
The tornado watch includes Lexington, Covington and Somerset and stretches east throughout the rest of Kentucky. A tornado was reported in the area 140 miles (225 kilometers) southwest of Memphis, Tennessee, at the time.
A tornado touched down and spun toward Enigma, Georgia, on Sunday, after 17 twisters were reported on Saturday and Sunday across the South from Texas to Alabama.