"We congratulate Lori Lightfoot on her victory and look forward to working closely with her as the first openly LGBTQ and Black female mayor of Chicago to ensure the city moves forward to be an inclusive and welcoming place for everyone".
Lightfoot, 56, campaigned to end political corruption and help lower-income families, adding that she would bring investments to the predominantly black South and West sides of the city.
She will join seven other black women now serving as mayors in major US cities, including Atlanta and New Orleans, and will be the second woman to lead Chicago. "We can and we will break this city's endless cycle of corruption and never again - never ever - allow politicians to profit from elected positions".
"What's also historic for me is she reached out very successfully to the white ethnic community, where you have traditional Polish, German, Irish-type people".
Martin Preib of the Fraternal Order of Police says Lightfoot's appeal is "disappointing".
Despite that, her supporters were pleased. In 2015, now-outgoing Mayor Rahm Emanuel appointed her to head the Chicago Police Board.
She was also bothered by Preckwinkle's association with longtime Alderman Ed Burke, who was indicted earlier this year on charges he tried to shake down a restaurant owner who wanted to build in his ward. "Building channels for people to believe that the city sees them and hears them and is willing to invest, is going to be critically important, and we have to start that right away".
"Every child out there should know this: Each of you, one day, can be the Mayor of Chicago" she said.
"I think it's worth noting that we outlined some of the same challenges, particularly investments in our neighborhoods, many of whom have struggled for decades with disinvestment and neglect", she said.
Rev. Jesse Jackson whispers to Chicago Mayor-elect Lori Lightfoot during a press conference at the Rainbow PUSH organization, Wednesday, April 3, 2019, in Chicago.
Parker, who's now executive director of the Gay & Lesbian Victory Fund, was on the ground in Chicago and commended Lightfood in a statement.
Since 1837, Chicago - the third largest city in the United States with some 2.7 million people - has chosen only one other black mayor and one other female mayor, although Lightfoot is the first openly-gay municipal chief executive.
"I voted for Lori Lightfoot".
The general election in February had 14 candidates, with Lightfoot and Preckwinkle as the top two vote-getters.
Meanwhile, advocates for gay rights have welcomed Lightfoot's win.
University of MI graduate Lori Lightfoot made history on Tuesday night when she won Chicago's mayoral race.