A handful of senators have sent out tweets that praised McCain but never named Trump.
President Donald Trump visited an Army tank plant in OH on Wednesday to bask in the afterglow of the facility's revival - one of several accomplishments he cast as ignored or insufficiently credited during a politically charged address to workers.
"I gave him the kind of funeral that he wanted, which as president I had to approve".
Isakson said that Trump's insistence on trashing the Vietnam War veteran and longtime Republican leader came to a head with the president's most recent jab on Tuesday.
"I hope (Trump's) indecency to John's memory and to the McCain family will convince more officeholders that they can't ignore the damage Trump is doing to politics and to the country's well-being or remain silent despite their concerns", said Mark Salter, McCain's biographer.
In his latest criticisms, Trump called McCain's vote against repealing and replacing Obamacare "disgraceful".
Mrs. McCain's ill-advised tweet followed days of tweet-shots between President Trump and the McCains' daughter, Meghan.
Donald Trump renewed attacks on the late senator John McCain, stating he "never liked" the Arizona Republican and "probably never will". John McCain died past year of brain cancer; Trump was not invited to the funeral.
Amid the controversy, Senate Minority Leader Chuck Schumer, D-N.Y., announced Wednesday that he intends to introduce legislation to rename one of the Senate office buildings after the late Arizona senator.
Over the weekend, Trump tweeted - inaccurately - that McCain had leaked the controversial Russian Federation dossier alleging misconduct by the Trump presidential campaign.
Trump criticized McCain for cheerleading the "endless wars" in the Middle East that have been a "disaster" for America, costing the nation "tremendous wealth" and "tremendous lives".
"This is a psycho", Joy Behar said in regards to the Presidents comments.
After calling George Conway - or "Mr. Kellyanne Conway, as the president refers to him - a "stone cold LOSER and husband from hell" in a morning tweet, the president affirmed his opinion to reporters on the South Lawn before leaving for a speech in Ohio". McCain spent years in a Vietnam prison during the war.
"There are kids committing suicide because of cyberbullying online, there are people going through rough times, there are veterans who come back - we have 20 veterans a day committing suicide - focus on these issues", she continued.
Whether Isakson personifies the start of a broader GOP pushback against Trump is not clear.
"I just want to lay it on the line, that the country deserves better, the McCain family deserves better".
Sen. Mitt Romney, R-Utah, rallied to McCain's defense Wednesday.
"Everyone should give him and his family the respect, admiration, and peace they deserve", she wrote on Twitter. John McCain, but the Georgia Republican reiterated Wednesday that he will not be joining the effort to put McCain's name on the office building now named for a favorite son of his home state.