Sitcom actress and critically-acclaimed film director Penny Marshall has died at 75.
Marshall's publicist, Michelle Bega, said Marshall died in her Los Angeles home on Monday due to complications from diabetes.
"Our family is heartbroken over the passing of Penny Marshall", her family said in a statement obtained by PEOPLE.
The ABC sitcom ran for eight (mostly) glorious seasons in the 1970s and '80s - turning Marshall and co-star Cindy Williams into household names as they romped through prime time as Milwaukee-based brewery workers Laverne DeFazio and Shirley Feeney.
Marshall also had a sports connection in one of her television roles, playing Myra Turner, secretary to sportswriter Oscar Madison, on the TV series "The Odd Couple". "Hanks" reprimand "There's no crying in baseball", from "A League of Their Own", remains quoted on baseball diamonds everywhere. Her first real name recognition came with a recurring part as a put upon secretary "nobody" ever called lovely on "The Odd Couple". He created Laverne & Shirley. She followed it up by directing Robert De Niro and Robin Williams in the film version of Oliver Sacks' book Awakenings.
Penny Marshall attends an event on November 7, 2008, in New York City.
Marshall later admitted to ET at a special screening of the action comedy that she was "nervous about an industry screening" but added earnestly, "I hope it goes well".
Many noted characters from her lengthy list of guest spots on television shows throughout her career. I loved her. Funny, warm, a true individual and remarkable talent. And she transitioned from acting into directing and became a director - a full-time director; the sad thing is she didn't have a longer career because of her success.
"Her legacy really was one of a woman who touched every corner of Hollywood - TV, film, and both on screen and behind the camera", Lauren Zima, anchor of ET Live, told CBSN on Tuesday.
Marshall, known for her bluntness, described the success of the series this way: "We dared to be stupid".
Marshall reunited with Hanks on 1992's A League of Their Own.
Marshall's other directing credits included "Renaissance Man" (1994), with Danny DeVito as a teacher who tries to inspire Army recruits; "The Preacher's Wife" (1996), starring Denzel Washington and Whitney Houston in a remake of the 1947 Cary Grant-Loretta Young-David Niven fantasy drama "The Bishop's Wife"; and "Riding in Cars with Boys" (2001), starring Drew Barrymore in a drama about a teenager and the pregnancy that shapes the rest of her life. Marshall's brother, "Pretty Woman" director Garry Marshall, died in 2016.
ABC Ronny Marshall Hallin, center, with her sister and brother, Penny Marshall and Gary Marshall, niece, Tracy Reiner and nephew Scott Marshall at a taping of Celebrity Family Feud in 2015.
During the '70s and '80s, Bo Kaprall, show business veteran who calls Minnesota home, became friends with Marshall and her then-husband Rob Reiner, which landed him a job on the classic show "Laverne and Shirley".