During the storm, heavy snowfall and wind gusts up to 50 miles per hour are expected to impact the area. "We're asking drivers to help us in keeping them safe by remembering to slow down during severe weather and be prepared for reduced visibility and changing pavement conditions".
Snow and blowing snow closed several roads in the area, including Interstate 70.
To the west, parts of the Plains States were reporting 100 percent snow-and-ice-covered roads before noon today. Travelers should look out for rain transitioning with little notice into heavy, wet snow on Sunday afternoon.
The Nebraska State Patrol closed westbound I-80 between Lincoln and Omaha because of the crashes on Sunday morning, which included semitrailer trucks jackknifed across the highway.
The arrivals and departures board shows the delayed and canceled flights at Washington's Reagan National Airport after technical issues at a Federal Aviation Administration center in Virginia caused delays on Saturday, Aug. 15, 2015.
The National Weather Service published a "traveler's guide" Sunday evening, warning motorists that driving during a blizzard warning is "not advised".
The storm caused multiple highways and interstates to close across both Kansas and Missouri.
Kearney resident Amy Scott told the Kansas City Star her brother-in-law, his wife and their son were hoping to make it as far as Salina, Kan., on Sunday evening.
The weather already is responsible for the cancellation of almost 400 flights from area airports, and transportation officials said auto travel will be hazardous as well. "I'm just saying prayers for them and others who have to be out on the roads". Around 3-6 inches of snow is expected to hit those counties.
With up to a foot of snow expected to fall in the northwestern part of the city and suburbs, the storm could break a 123-year-old record for biggest snowstorm in Chicago in November.
Separately, a portion of Interstate 29 was shut down in Missouri, near the Iowa border.
Meteorologists say the heaviest snow is expected to be in southeast Nebraska, southwest Iowa and northwest Missouri where 8 to 12 inches could fall in towns such as Nebraska City, Falls City, Beatrice and Red Oak.
By Monday morning, the storm was expected to hit parts of northern IN and southern MI.