Rohit Sharma who has done exceptionally well with the bat and captainship will lead the young Indian side.
For left-arm orthodox Krunal, bowling figures of one for 15 off four overs was a great way to make a debut but it was Kuldeep Yadav who excelled once again at the Eden Gardens.
The highly-anticipated match will be played on November 4, Sunday, and it will start at 7 pm India time.
The Windies, who missed the big names in the Test and ODI series, will be bolstered by the arrival of star players Darren Bravo, Kieron Pollard and Andre Russell, who will be back at his IPL home venue. Despite losing Manish Pandey towards the end, Krunal's busy little cameo and Karthik's calm presence ensured the win was completed easily.
Where to Watch Live Telecast of India vs West Indies 2018, 1st T20 Match?
Elder brother of star all-rounder Hardik Pandya, Krunal was part of the squad for the three T20I series in England but did not get a game.
In 2018, Dhoni, who has also captained India to 50-over World Cup glory in 2011, managed only 245 runs at 27.22 in 17 matches.
Unlike India, the West Indies suffered early setbacks due to poor batting. The contest will be competed at Eden Gardens, in Kolkata.
Down with a "gastric complaint", Bhuvneshwar Kumar pulled out in the last minute despite being named in the XII, but his absence was hardly felt with Yadav and debutant and Khaleel doing a fine job.
The local crowd had been clearly silenced at one point following the meek surrender of a side that enthralled them two years ago to clinch the World T20 title and if not for some useful boundaries at the death, Windies wouldn't have crossed 100.
The visitors have beaten India in five of their seven meetings in T20Is - a comforting stat that should give the new-look West Indies a lot of confidence. The Eden track promises a run feast with a bit of grass on the surface affording even bounce and the ball expected to come on to the bat nicely.
Team India will play their next ODI series in Australia in January 2019 which means that he will finish the current year with 9999 runs.