The two teams will meet on Monday night at Old Trafford, where Tottenham have lost every Premier League game since January 2014 - the season before Pochettino was appointed.
Exactly why United did not bring in a new player in that department, whether it be Leicester City's Harry Maguire, Tottenham's Toby Alderweireld or Bayern Munich's Jerome Boateng who were all linked with the club, remains unclear.
Varane was a regular under Zinedine Zidane last season but new boss Julen Lopetegui has started Nacho ahead of the French worldwide so far this season and it looks like Man Utd are ready to pounce if the situation continues.
"Three wins out of three - it's been a fantastic start", said the 25-year-old.
Only two other current managers in the Premier League have won titles in English's top flight: Manchester City's Pep Guardiola, who won last season's title with the club, and West Ham's Manuel Pelligrini, who won the 2013-14 premiership title with Manchester City. Three-nil. But it also means three premierships (EPL titles), and I've won more premierships alone than the other 19 managers together.
Manchester United's start to the season has gone from bad to worse.
Having held up three fingers to emphasise his point, he then stormed out of the conference, muttering: "Respect, respect, respect, man". It has been 49 years since they collected the ball from their own net so much in their first three games.
"No", he said. "Because in the first game Lindelof and Bailly, now Jones and Smalling but now Jones is injured and in the next match will be Smalling with another one and when Marcos Rojo comes he will also be an option". "It is only the start of the season and we need to be consistent. The competition for places is high and we've just to keep it going".
"To the fans who came out, we're sorry".
"Today I had the proof - the best judge in the football are the supporters". He even predicted this would happen in one of his gloomy preseason statements, when he said "it will be a hard season for us" if he didn't get any defensive reinforcements (which he didn't).
"I just think that if anyone that watched this game...one thing they know for sure, the team is united". Whatever the pain and frustration at losing, these symbols of United's core values displayed their class and dignity.
"We have a really good group and yeah of course we'll reflect on our day off (on Tuesday) and we'll come back in on Wednesday".