"Me and my love Sofia talking about Bieber and Owls and Basketball", the rapper wrote on his Instagram post. "I hope you can come and cheer me up". The first was to be given a new heart, and the second was to meet Drake.
A heart transplant is often needed to survive, and Sofia is now on the waiting list.
The rapper shared photos of himself with Sofia Sanchez, who has heart failure, onto Instagram.
Drake, in a surprise visit, granted one of two of Sanchez's birthday wishes (the other being to receive a new heart).
An 11-year-old girl awaiting a heart transplant had her spirits lifted when she received a surprise visit from Drake on Monday. Sofia screamed 'Oh my God!' as he entered the room and Drake casually responded: "You asked me to come, I'm here".
Drake was in Chicago this weekend performing at the United Center.
Three weeks ago, Sanchez underwent open heart surgery in order to receive a VAD (ventricular assist device) that will help her heart pump blood.
Just last week, Sanchez - who suffers cardiomyopathy, a condition that often leads to heart failure and need for heart transplantation in order to survive - and her cousin did the "In My Feelings" Challenge while at the hospital with the hope of meeting her idol. Most often, it serves as a bridge to heart transplantation. Lurie Children's heart transplant team has performed 22 heart transplants so far this year.
And Drake made Sofia's wish come true by surprising her on the ward.