The United manager's relationship with the likes of Anthony Martial and Paul Pogba, both of whom would leave Old Trafford if there was an exit route, has been severely strained for some time, but there are others in the dressing room who have exhausted of Mourinho's approach on and off the field.
Mark Ogden says the current situation at Manchester United is untenable, with a clear disconnect between the players, Jose Mourinho and Ed Woodward.
Duffy was also presented with the Sky Sports Man of the Match award after the game.
Ince was not the only one piling in yesterday, with Gary Neville stepping into the war of words between Paul Scholes and Pogba's agent Raiola.
Finally United had got one up on Pep and his army of talent, but fast forward eight months and it is fair to say that things haven't worked out the way Jose Mourinho had hoped.
Manchester United fans watched on as yet another spineless, gutless and unimaginative performance from their team unfolded before their eyes as they lost once more away to Brighton.
"You don't need other people to tell you".
"When you see Man City, Liverpool, Chelsea and Tottenham - they're all playing the kind of football you expect from a Manchester United side".
"Some of the things he's done and said, even last season, left you thinking 'why are you doing this?'"
"But they are all about attacking football, feel-good factor, the Theatre of Dreams, winning trophies with a smile and swagger".
Woodward will at least try to address the woeful lack of long-term strategy by appointing a technical director before the January window, with former goalkeeper Edwin van der Sar a strong candidate, but there are more pressing issues, such as Pogba.
He said: "Should Mourinho leave? No". This has caused Mino Raiola to ask that United transfer the player.
Paul Pogba? He had a bad agent.
I look at Jurgen Klopp at Liverpool and while he has not won the trophies Mourinho has collected over the course or his career, he has a wonderful way of getting players on side and presenting his club in a good light.