Tactical officers from the Fourth District were trying to stop the vehicle for an undisclosed reason about 9:35 p.m.in the 7900 block of South Essex Avenue when the man got out of the back seat and started running, police said. A confrontation then ensued and the man was shot, Guglielmi said.
At least four people have been arrested and several officers were injured with rocks and bottles, Chicago police spokesman Anthony Guglielmi tweeted.
A weapon was recovered at the scene, Guglielmi said, but he did not say whether the man was armed when he was shot at around 5:30 p.m. local time, Fox 32 Chicago reported.
After nightfall, protesters continued to mill around the neighbourhood with police occasionally chasing them away. Video showed several police officers and protesters shoving each other.
Just hours after the shooting, the Chicago Police Department released a preliminary statement about the shooting saying the officer who fired the shots would be "placed on routine administrative duties for a period of 30 days". Angry crowd & police clash after officer involved shooting.
Protesters were seen approaching and shouting at the police officer cordon.
Saturday's confrontation is the latest incident illustrating the deep-seated mistrust between residents of Chicago's predominantly black and Latino neighbourhoods and police.
Chicago Sun-Times reporter Issa told Al Jazeera that "the tension between the community and the police [on Saturday] hasn't felt this high since the video of Laquan McDonald's shooting was released".
When police with batons entered a parking lot where protesters were gathered near the scene, scores of people scattered.
Randale Truitt, 31, of the 200 block of East 70th Street, is charged with attempted first-degree murder. McDonald's death led to the ouster of the police chief and a series of reforms created to prevent future police abuses and to hold officers accountable for excesses.
The Guardian identified more than 1,090 police killings the previous year.
Gloria Rainge, 41, says she was leaving a Walgreens when she noticed a cop telling the man to stop selling cigarettes.